Developing Exposure/Response Models for Anticancer Drug Treatment: Special Considerations

Developing Exposure/Response Models for Anticancer Drug Treatment: Special Considerations

Anticancer agents often have a narrow therapeutic index (TI), requiring precise dosing to ensure sufficient exposure for clinical activity while minimizing toxicity. These agents frequently have complex pharmacology, and combination therapy may cause schedule-specific effects and interactions. We review anticancer drug development, showing how integration of modeling and simulation throughout d...

Special considerations for geriatric therapeutic drug monitoring.

Numerous physiological changes during the normal aging process can potentially affect how drugs are handled by the body. Gastrointestinal changes include increased gastric pH, decreased intestinal motility, and decreased blood perfusion. Age-related changes in body composition and protein concentrations in plasma contribute to alterations in the distribution of drugs. Hepatic metabolism of drug...

Special Considerations in Treatment for Adults

Adjunctive orthodontic treatment for adults is, by definition, tooth movement carried out to facilitate other dental procedures necessary to control disease, restore function and/or enhance appearance. Almost always, it involves only a part of the dentition, and the primary goal usually is to make it easier or more effective to replace missing or damaged teeth. Making it easier for the patient ...

Special Considerations in Air Travel for Pregnant Women

Self-assembly drug conjugates for anticancer treatment.

Self-assembly drug conjugate preparation is a promising approach to improve activity and penetration through physiological barriers of potent small molecules, as well as to reduce any side effects. Drug conjugates can self-assemble in water to form nanoparticles (NPs) that offer several advantages because: (i) they are easy to obtain; (ii) they can reach high local drug concentration in tumor t...